糖心视频

 

任吉存教授

办公电话:021-54746001
电子邮件:[email protected]
通讯地址:上海市东川路800号糖心视频 A楼216室

  • 教育背景

    1978-1981:安庆师范糖心视频 化学系,学士
    1991-1994:武汉大学化学系, 博士
    1994-1996:中南大学湘雅医糖心视频 ,博士后
    1996-2000:挪威卑尔根大学医糖心视频 ,博士后

  • 工作经历

    1982-1991:安庆师范糖心视频 化学系,助教,讲师
    1994-1996:湖南师范大学化学系,副教授
    1997-2001:湖南师范大学化学系,教授
    2001-2015:糖心视频 ,教授

    2015 -     糖心视频 ,特聘教授

  • 研究方向

    (1)单分子(单颗粒)波动光谱与成像: 发展单分子(单颗粒)波动光谱与成像新方法,与微流控芯片技术结合,研究活细胞内生物分子、药物分子的动力学以及分子间(药物分子与靶标、蛋白-蛋白)的相互作用。

    (2)光学探针设计与合成:设计合成新型的纳米光学探针和荧光分子探针,发展活细胞内生物分子的标记新方法。

    (3)生物分析:基于微流控芯片电泳和纳米光学探针标记技术,发展高灵敏度的分析新方法,用于疾病标志物、环境污染物分析。

  • 科研项目

    主持国家重大科研仪器研制项目、国家自然科学基金重点项目、面上项目,科技部“863”专项,上海科委重点项目等。

  • 代表性论文专著

    论文

    Liyuan Deng, Xiangyi Huang*, Jicun Ren*, In Situ Study of the Drug–Target Protein Interaction in Single Living Cells by Combining Fluorescence Correlation Spectroscopy with Affinity Probes, Anal. Chem. ©2020 糖心视频-糖心-糖心视频入口版权所有 , 92, 7020–7027.


    Shengrong Yu, Fucai Li, Xiangyi Huang, Chaoqing Dong,* and Jicun Ren*


    In Situ Study of Interactions between Endogenous c-myc mRNA with CRDBP in a Single Living Cell by Combining Fluorescence Cross Correlation Spectroscopy with Molecular Beacons,


    Anal. Chem., ©2020 糖心视频-糖心-糖心视频入口版权所有 , 92, 2988-2996.


    Zhixue Du, Jing Yu, Fucai Li, Liyun Deng, Fang Wu, Xiangyi Huang, Jan Bergstrand, Jerker Widengren, Chaoqing Dong* and Jicun Ren* In situ monitoring p53 protein and MDM2 protein interaction in single living cells using single molecule fluorescence spectroscopy, Anal. Chem., 2018, 90, 6144−6151.


    Lvping Cai, Liyun Deng, Xiangyi Huang*, Jicun Ren*, Catalytic Chemiluminescence Polymer Dots for Ultrasensitive In Vivo Imaging of Intrinsic Reactive Oxygen Species in Mice, Anal. Chem., 2018, 90, 6929−6935.


    Di Su, Chaoqing Dong and Jicun Ren* Quantitative Determination of Telomerase Activity by Combining Fluorescence Correlation Spectroscopy with Telomerase Repeat Amplification Protocol, Anal. Chem., 2018, 90, 10006-1013. 


    Fang Yi, Xiangyi Huang, Jicun Ren, Simple and Sensitive Method for Determination of Protein Kinase Activity Based on Surface Charge Change of Peptide-Modified Gold Nanoparticles As Substrates, Anal. Chem., 2018, 90, 3871−3877.


    Bocheng Zhang, Chaoqing Dong and Jicun Ren* Size Distribution of Noble Metal Nanoparticles Characterized by Combing Resonance Light Scattering Correlation Spectroscopy with Maximum Entropy Method , Anal. Chem., 2017, 89 (22), 12609–12616.


    Di Su, Chaoqing Dong, and Jicun Ren* Determination of caspase-3 activity and its inhibition constant by combination of fluorescence correlation spectroscopy with a microwell chip,


    Anal. Chem., 2017, 89, 9788−9796.


    Jinjie Wang, Chaoqing Dong, Jicun Ren* Fluorescence and scattering light cross correlation spectroscopy and its applications in homogeneous immunoassay, Anal. Chem., 2017,89, 5230−5237.


    Aidi Zhang, Chaoqing Dong*, and Jicun Ren* Tuning Blinking Behavior of Highly Luminescent Cesium Lead Halide Nanocrystals through Fast Anion-Exchange Reactions, J. Phys. Chem. C, 2017, 121, 13314−13323.


    Heng Liu, Chaoqing Dong, Jicun Ren*, Tempo-Spatially Resolved Scattering Correlation Spectroscopy Based on Dark-Field Microscopy and Its Application to Investigate Dynamic Behaviors of Gold Nanoparticles in Live Cells, 


    J. Am. Chem. Soc., 2014, 136, 2775−2785.


    Chaoqing Dong*, Heng Liu, Aidi Zhang, Jicun Ren*Controllable Blinking-to-Nonblinking Behavior of Aqueous CdTeS Alloyed Quantum Dots, Chem. Eur. J. 2014, 20(7): 1940-1946.


     Chaoqing Dong*, Heng Liu, Jicun Ren* Assessing the blinking state of fluorescent quantum dots in free solution by combining fluorescence correlation spectroscopy with ensemble spectroscopic methods, Langmuir,2014, 30, 12969−12976.


     Aidi Zhang, Chaoqing Dong, Heng Liu and Jicun Ren*, Blinking Behavior of CdSe/CdS Quantum Dots Controlled by Alkylthiols as Surface Trap Modifiers, J. Phys. Chem. C, 2013, 117, 24592−24600.


    Bocheng Zhang, Tao Lan, Xiangyi Huang, Chaoqing Dong and Jicun Ren*, Sensitive Single Particle Method for Characterizing Rapid Rotational and Translational Diffusion and Aspect Ratio of Anisotropic Nanoparticles and Its Application in Immunoassays Anal. Chem., 2013, 85, 9433−9438.


    Xiangyi Huang, Jicun Ren*, Nanoparticle-Based Chemiluminescence Resonance Energy Transfer: A strategy to develop new analytical methods, TrAC:Trends in Analytical Chemistry, 2012, 40, 77-89.


    Lingao Ruan, Zhancheng Xu, Tao Lan, Jinjie Wang, Heng Liu, Chaodong Li Chaoqing Dong, Jicun Ren*, Highly Sensitive Method for Assay of Drug-induced Apoptosis Using Fluorescence Correlation Spectroscopy, Anal. Chem., 2012, 84, 7350−7358.


    Heng Liu, Chaoqing Dong, Xiangyi Huang, Jicun Ren*, Spatially Resolved Scattering Correlation Spectroscopy Using A Total Internal Reflection (TIR) Configuration , Anal. Chem., 2012, 84, 3561−3567.


    Jie Gao, Xiangyi Huang, Heng Liu, Feng Zan, Jicun Ren *, Colloidal stability of gold nanoparticles modified with thiol compounds, bioconjugation and application in cancer cell imaging, Langmuir, 2012, 28, 4464-4471.


    Feng Zan, Chaoqing Dong, Heng Liu, Jicun Ren* Experimental studies on blinking behavior of single InP/ZnS quantum dots: Effects of synthetic conditions and UV irradiation, J. Phys. Chem. C, 2012, 116, 3944−3950.


    Feng Zan, Jicun Ren* Gas-liquid phase synthesis of highly luminescent InP/ZnS core/shell quantum dots using zinc phosphide as a new phosphorus source, J. Mater. Chem., 2012, 22, 1794-1799.


    Hua He, Chao Xie, Jicun Ren*, Non-Bleaching Fluorescence of Gold Nanoparticles and Its Applications in Cancer Cell Imaging,  Anal. Chem., 2008, 80, 5951-5957.


    Chaoqing Dong, Jiacheng Guo, Liwen Shao, Jicun Ren* Host-guest interaction of chaperonin GroEL and water soluble CdTe QDs and its size selective encapsulation, ChemPhysChem., 2008, 9, 2245-2251.


    Huifeng Qian, Chaoqing Dong, Jinliang Peng, Xin Qiu, Yuhong Xu, Jicun Ren*, High Quality and Water-Soluble Near-Infrared Photoluminescent CdHgTe/CdS Quantum Dots Prepared by Adjusting Size and Composition,J. Phys. Chem. C., 2007, 111, 16852-16857.


    Kanglin Wang, Xin Qiu, Chaoqing Dong, Jicun Ren*, Single molecule technology for rapid detection of DNA hybridization based on resonance light scattering of gold nanoparticles as probes, ChemBioChem., 2007, 8, 1126-1129.


    Chaoqing Dong, Jicun Ren*, On-line investigation of laser-induced aggregation and photo-activation of CdTe quantum dots by fluorescence correlation spectroscopy,  J. Phys. Chem. C, 2007, 111, 7918-7923.


    Hua He, Huifeng Qian, Chaoqing Dong, Kanglin Wang,Jicun Ren*, Single Nonblinking CdTe Quantum Dots Synthesized in Aqueous Thiopropionic Acid, Angew. Chem. Int. Ed. 2006, 45, 7588-7591.


    Xiangyi Huang, Liang Li, Huifeng Qian, Chaoqing Dong, Jicun Ren* A Resonance Energy Transfer between Chemiluminescence Donors and CdTe Quantum Dots Acceptors (CRET), Angew. Chem. Int. Ed., 2006, 45, 5140-5143.


    Chaoqing Dong, Huifeng Qian, Nenghu Fang and Jicun Ren*, Study of Fluorescence Quenching and Dialysis Process of CdTe Quantum Dot Using Ensemble Techniques and Fluorescence Correlation Spectroscopy, J. Phys. Chem. B, 2006, 110,11069-11075.


    Huifeng Qian, Xing Qiu, Liang Li, Jicun Ren* Microwave assisted aqueous synthesis: a rapid approach to prepare highly luminescent ZnSe(S) alloyed quantum dots, J. Phys. Chem. B, 2006, 110, 9034-9040.


    Jifang Weng, Jicun Ren*, Luminescent Quantum Dots:  An Attractive Promising Tool in Biomedicine, Current Medicinal Chemistry, 2006, 13, 897-909.


    Huifeng Qian, Jicun Ren*, Facile one-pot synthesis of highly luminescent, water-soluble and bio-compatible glutathione coated CdTe quantum Dots in aqueous phase, Small, 2006, 2,747-751.


    Xiangyi Huang, Jicun Ren*,  Chemiluminescence detection in capillary electrophoresis and microchip capillary electrophoresis,  TRAC:Trends in Analytical Chemistry, 2006, 25,155-156.


    Chaoqing Dong, Rui Bi, Huifeng Qian, Jicun Ren* Coupling fluorescence correlation Spectroscopy with Microchip Electrophoresis to Determine Effective Surface Charge of Water-Soluble QDs, Small, 2006, 2,534-538.


    Liang Li, Huifeng Qian, Jicun Ren*,CdTe@Co(OH)(core/shell) nanoparticles: aqueous synthesis and characterizations, Chemical Communication,2005, 4083-4085.


    Liang Li, Huifeng Qian, Jicun Ren*, Rapid Synthesis of Highly Luminescent CdTe Nanocrystals in Aqueous Phase by Microwave Irradiation with Controllable Temperature, Chemical Communication, 2005, 528-530.


    Jicun Ren*, Arve Ulvik, Helga Refsum, Per Magne Ueland , Uracil in Human DNA from Subjects with Normal and Impaired Folate Status, as Determined by High Performance Liquid Chromatography-Tandem Mass, Analytical Chemistry, 2002, 74, 295-299.


    Jicun Ren*, Xiangyi Huang, Highly Sensitive and Universal Indirect Chemiluminescence Detection for Capillary Electrophoresis of Cations Using Cobalt(II) As A Novel Probe Ion,  Analytical Chemistry, 2001, 73, 2663-2668.


    专著

    Jicun Ren, 《Capillary Electrophoresis of Nucleic Acid》, Chapter 10 and Chapter 19, Jan., 2001, Humana Press Inc., Totowa, NJ, USA.


  • 学术兼职

    Electrophoresis (Wiley), Microchimica Acta (Springer),  Journal of Separation Science (Wiley), Methods and Applications in Fluorescence (IOP),《分析化学》,《色谱》等杂志编委, 国际荧光光谱学方法和应用大会(Methods and Applications in Fluorescence, MAF) 督导委员会委员(Permanent Steering Committee )。

  • 荣誉奖励

    ©2020 糖心视频-糖心-糖心视频入口版权所有 年获国务院政府特殊津贴

    2016年获教育部自然科学一等奖

    2015年糖心视频 特聘教授

    2008年获教育部自然科学二等奖

  • 教学工作

    本科生:《仪器分析》
    研究生:《现代仪器分析》

地址:上海市东川路800号 200240
电话:021-54742893
E-mail:sjtutangxinsp.net

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